Lourenco Lab https://validator.w3.org/feed/docs/rss2.html Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease Home Symposium News in Veja Highlights Recent Publication in Mol Psy News at Super Interessante Featured Recent Publication in Mol Psy News in Estadão Highlights Recent Publication by the Group News in Folha de S. Paulo Highlights Recent Publication by the Group How does chronic pain lead to memory loss? Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts Lab News Team Collaborators Funding The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease News in O Globo about Dr. Mychael’s research Gallery Dr. Mychael interviewed by Casa Firjan on healthy habits for a better future In the News Genetic reduction of the translational repressors FMRP and 4E-BP2 preserves memory in mouse models of Alzheimer’s disease Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans Column highlights Dr. Mychael’s article Resources PI Effects of Gestational Exercise on Nociception, BDNF, and Irisin Levels in an Animal Model of ADHD Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice Irisin limits amyloid-β buildup in Alzheimer’s disease News on TV Cultura Highlights Recent Publication Amyloid-β oligomers in cellular models of Alzheimer’s disease. Cerebrospinal Fluid Neurotransmitters, Cytokines, and Chemokines in Alzheimer’s and Lewy Body Diseases. d-serine levels in Alzheimer’s disease: implications for novel biomarker development. Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease. Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease. 2,4-Dinitrophenol induces neural differentiation of murine embryonic stem cells. How does brain insulin resistance develop in Alzheimer’s disease? TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s β-amyloid oligomers in mice and monkeys. Targeting Alzheimer’s pathology through PPARγ signaling: modulation of microglial function. Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice. Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons. Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer’s disease and diabetes. Integrated Stress Response: Connecting ApoE4 to Memory Impairment in Alzheimer’s Disease. Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students. The malleable brain: plasticity of neural circuits and behavior – a review from students to students. Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches. Challenges for Alzheimer’s Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD. Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease. How does the skeletal muscle communicate with the brain in health and disease? Editorial: Honouring John Hardy – A true pioneer in research. Bios